Born into a Bengali family, Mukherji grew up in Kolkata, India where she studied at South Point School. She received her musical training at Dakshinee, a prominent Rabindra Sangeet academy in Kolkata, and obtained a degree in English literature from Jadavpur University, where she also won a Gates Cambridge Scholarship.She pursued post graduate studies in English literature from St. John's College in the UK and Collegio Ghislieri, at the University of Pavia, Italy.
Mukherji performed her debut solo concert in Kolkata in September, 2009.She has since performed extensively in India and abroad including at the North American Bengali Conferences on three occasions – in 2012 (Las Vegas),2013 (Toronto),and 2016 (New York City).
Mukherji has attempted to introduce innovation to her Rabindra Sangeet performances. In 2011, she performed a concert titled Nutan Juger Bhore (English:The Dawning of a New Era), accompanied by an 11-piece orchestra, which is unusual for the genre.
In 2012 Mukherji sang for a music album Romancing Tagore, that was a collaborative effort between Indian and Pakistani artists, Shubha Mudgal, Najam Sheraz, Debojyoti Mishra, and Indira Varma to present Tagore's songs in Urdu.Prime Minister Manmohan Singh released the album in February 2012.
In April 2012, Mukherji visited Mauritius as part of a joint initiative between UNESCO and the Ministry of Culture of the Government of Mauritius on the occasion of Rabindranath Tagore's 150th birth anniversary.The purpose of the trip was to introduce the musical work of Tagore to school children in that country
In 2015, Mukherji presented a solo concert for the President of India, to celebrate the 154th Birth Anniversary of Tagore, at the Rashtrapati Bhavan, New Delhi.
